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Beta-carotene orally when combined with vitamin C, vitamin E, and zinc appeared to supply a 27% threat reduction for visible loss ensuing from macular degeneration and may contribute to arresting progression to advanced macular degeneration. Nutritional supplements are regulated by the US Food and Drug Administration under the Dietary Supplement Health and Education Act of 1994 . 2018 The mandate of the EFSA NDA Panel is broadened to incorporate the evaluation of nutrient sources and requests for security evaluation under Art. 8 of Regulation No 1925/2006. In December 2017, EFSA published the Summary report on Dietary Reference Values for nutrients.

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